David T W Jones Selected Research

Astrocytoma (Pilocytic Astrocytoma)

11/2022	Distinct DNA Methylation Patterns of Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex.
6/2021	High-Resolution Cartography of the Transcriptome and Methylome Landscapes of Diffuse Gliomas.
1/2021	A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR.
1/2020	Pilocytic astrocytoma demethylation and transcriptional landscapes link bZIP transcription factors to immune response.
1/2019	Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
1/2019	The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma.
12/2018	Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK.
10/2018	Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations.
1/2018	Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations.
1/2018	The case for DNA methylation based molecular profiling to improve diagnostic accuracy for central nervous system embryonal tumors (not otherwise specified) in adults.

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David T W Jones Research Topics

Disease

98	Neoplasms (Cancer) 02/2022 - 08/2009
34	Glioma (Gliomas) 10/2022 - 09/2012
28	Medulloblastoma 01/2021 - 04/2012
22	Astrocytoma (Pilocytic Astrocytoma) 11/2022 - 11/2008
16	Glioblastoma (Glioblastoma Multiforme) 06/2021 - 08/2009
10	Brain Neoplasms (Brain Tumor) 11/2022 - 03/2013
7	Carcinogenesis 01/2022 - 04/2012
6	Oligodendroglioma 06/2021 - 02/2014
5	Primitive Neuroectodermal Tumors (PNET) 01/2021 - 01/2016
5	Ependymoma 01/2019 - 01/2016
4	Disease Progression 06/2022 - 05/2013
4	Meningioma (Meningiomas) 12/2021 - 03/2013
4	Genomic Instability 11/2021 - 06/2016
4	Diffuse Intrinsic Pontine Glioma 01/2021 - 01/2017
3	Neuroepithelial Neoplasms (Gliomatosis Cerebri) 01/2017 - 01/2016
2	Neuroblastoma 09/2021 - 01/2021
2	Exanthema (Rash) 09/2020 - 01/2019
2	Pinealoma (Pineoblastoma) 01/2020 - 01/2018
2	Nervous System Neoplasms (Neoplasms, Nervous System) 01/2019 - 03/2015
2	Typical Teratoid Rhabdoid Tumor 01/2019 - 12/2012
2	Ganglioglioma 10/2018 - 01/2017
2	Sarcoma (Soft Tissue Sarcoma) 01/2018 - 01/2016
2	Chromothripsis 06/2016 - 08/2012
2	Neoplasm Metastasis (Metastasis) 01/2016 - 11/2013
2	Intellectual Disability (Idiocy) 11/2012 - 01/2012
1	Tuberous Sclerosis (Bourneville's Disease) 11/2022
1	Pleomorphic Adenoma 11/2021
1	Second Primary Neoplasms (Neoplasms, Second) 01/2021
1	Turcot syndrome 01/2021
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2021
1	Paronychia 09/2020
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2020
1	Neurofibromatoses (Neurofibromatosis) 01/2019

Drug/Important Bio-Agent (IBA)

19	Biological ProductsIBA 01/2021 - 04/2012
16	Biomarkers (Surrogate Marker)IBA 06/2022 - 05/2013
15	Proteins (Proteins, Gene)FDA Link 01/2021 - 08/2009
15	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 03/2013
13	RNA (Ribonucleic Acid)IBA 11/2021 - 08/2012
12	Pharmaceutical PreparationsIBA 02/2022 - 06/2011
12	Histones (Histone)IBA 12/2020 - 01/2012
10	ChromatinIBA 01/2019 - 01/2012
8	dipinacoline glutamateIBA 01/2021 - 01/2016
7	Formaldehyde (Formol)FDA Link 11/2019 - 11/2013
7	ParaffinIBA 11/2019 - 11/2013
6	Phosphotransferases (Kinase)IBA 01/2022 - 11/2008
6	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 06/2021 - 08/2009
6	Messenger RNA (mRNA)IBA 01/2020 - 07/2011
5	MicroRNAs (MicroRNA)IBA 01/2021 - 12/2012
4	Mitogen-Activated Protein KinasesIBA 09/2020 - 08/2013
4	NucleotidesIBA 12/2019 - 01/2016
4	Temozolomide (Temodar)FDA LinkGeneric 01/2019 - 09/2012
3	2,6-dinitrotoluene (DNT)IBA 10/2022 - 01/2017
3	Transcription Factors (Transcription Factor)IBA 01/2022 - 07/2014
3	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2021 - 12/2013
3	Small Interfering RNA (siRNA)IBA 11/2019 - 02/2014
3	hydrogen sulfite (bisulfite)IBA 05/2019 - 09/2012
3	MethyltransferasesIBA 01/2019 - 01/2018
2	Protein Isoforms (Isoforms)IBA 01/2022 - 07/2014
2	ProteomeIBA 01/2021 - 01/2020
2	CateninsIBA 01/2019 - 08/2012
2	Lysine (L-Lysine)FDA Link 11/2018 - 03/2013
2	RNA Helicases (RNA Helicase)IBA 05/2016 - 08/2012
2	Codon (Codons)IBA 01/2016 - 08/2009
1	trans-sodium crocetinate (crocetin)IBA 11/2022
1	Sirolimus (Rapamycin)FDA Link 11/2022
1	human MIRN376A1 microRNAIBA 06/2022
1	tyrosine receptor (receptor, tyrosine)IBA 01/2022
1	Proto-Oncogene Proteins c-etsIBA 01/2022
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 11/2021
1	Histone Deacetylase InhibitorsIBA 09/2021
1	eprenetapoptIBA 09/2021
1	Indicators and Reagents (Reagents)IBA 01/2021
1	Arsenic Trioxide (Trisenox)FDA Link 01/2021
1	ErbB Receptors (EGF Receptor)IBA 01/2021
1	entrectinibIBA 12/2020
1	Valine (L-Valine)FDA Link 12/2020
1	Arginine (L-Arginine)FDA Link 12/2020
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 12/2020
1	trametinibIBA 09/2020
1	entinostat (MS 275)IBA 06/2020
1	NivolumabIBA 06/2020
1	NeurocalcinIBA 01/2020
1	Basic-Leucine Zipper Transcription FactorsIBA 01/2020
1	ponatinibIBA 11/2019
1	LB100IBA 11/2019
1	Creatine Kinase (Creatine Phosphokinase)IBA 01/2019
1	Conditioned Culture MediaIBA 01/2019
1	AZD 6244IBA 01/2019
1	1,4-dinitro-2-methyl-2-buteneIBA 01/2019

Therapy/Procedure

42	Therapeutics 02/2022 - 04/2011
9	Drug Therapy (Chemotherapy) 01/2022 - 08/2012
5	Precision Medicine 06/2022 - 01/2016
4	Radiotherapy 01/2021 - 01/2016
3	Investigational Therapies (Experimental Therapy) 01/2019 - 01/2016
3	Chemoradiotherapy 01/2018 - 01/2016
2	Aftercare (After-Treatment) 01/2021 - 01/2016
2	Ligation 11/2014 - 05/2013
1	Cranial Irradiation 01/2021
1	Combined Modality Therapy 12/2020
1	Drug Tapering 09/2020